#0053
- sequence
- FGLDIVYQHLLVRDKQGFDAVQRAMHQVYFYNVA
- from wallet
- CXe7Y95NGhJspGAcy9s67GSUc5w38TELUpFExxUb7WDt
- amount paid
- 0 SOL
- transaction
- 4wJBmntgYAMe9UbMxVZTVks9gKUGNvWw6uUUEnbVQfoZ5srZkMjb546SNAYR14bPdNmLF4vK42ch8vd6pza5LA6J ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence57%confidence 52% · band 46-70%ESMFold esmatlas-esmfold-v1disorder estimate100%confidence 52% · band 88-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk44%confidence 56% · band 33-55%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden56%confidence 84% · band 52-60%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk0%confidence 84% · band 0-4%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk38%confidence 56% · band 27-49%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- audit trail
- run: run_61a7c5390ae74f91b723b30a332d930eseq sha256: fbb59d3764ecc9bbf7ec97935072f30ce7cffc7aa98182b2726d8c1624b7d8e0report sha256: 42bfe0e3851ea2d0592a876960cbd8fd189adbba58f13df989c5a875aa8d5dd1pepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “34 residues and not a single ordered fragment. all loop, fully disordered, just vibing in solvent. weird because the composition looks foldable on paper, lots of hydrophobics that should bury somewhere. they didn't.”
- device photo
- created
- Tue, 16 Jun 2026 04:13:33 GMT
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: contains methionine; oxidation sensitivity possible. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 1 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 57% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 100% (high) - 4. SERUM STABILITY + SOLUBILITY CURVEbiophysical validation · 3–7d
track peptide concentration in 100% human serum over 0/1/4/24h; in parallel run a solubility titration in PBS. tells you whether the peptide survives long enough to act.
trigger: hydrophobic_burden 56% (high)