specimen
#0477
status: complete
- sequence
- IADIPLMPKIGILGVKLFQPEKGKA
- from wallet
- BB4xvQTGTQZVPaQZmhiuVkL3RZQgj4222SoG6RwyhkBo
- amount paid
- 0 SOL
- transaction
- 661wfkEgCQYGs3GxvYutx55RquuGMKjinZ7FHShh1Nb6HbvKZRjmLX2RjGphGpi8sYpHfMAgEfij26CCfU2rDNMv ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence60%confidence 52% · band 48-72%ESMFold esmatlas-esmfold-v1disorder estimate100%confidence 52% · band 88-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk38%confidence 56% · band 27-49%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden48%confidence 84% · band 44-52%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk8%confidence 84% · band 4-12%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk34%confidence 56% · band 23-45%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- audit trail
- run: run_3c47ca6ee28f411eb296ad775eb596f6seq sha256: 68a2534ccaf8a683889890ccb9947b1d378dcad9bbe975d154a02b585a6664c9report sha256: c579d45349d3e6ca51293b900aa0b40e230008373838673ef48930a243456e93pepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “all loop, no commitment. 25 residues of pure flop despite a decent hydrophobic core that should know better. the prolines probably broke whatever helix wanted to form here.”
- device photo
- created
- Wed, 24 Jun 2026 13:44:54 GMT
- completed
- Wed, 24 Jun 2026 14:15:57 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: contains methionine; oxidation sensitivity possible. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 1 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 60% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 100% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.