specimen

#0476

status: complete
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sequence
EDGTVLGPPKKKKGRQD
amount paid
0 SOL
structure
0% helix · 0% sheet · 100% loop
actionable triage
fold confidence80%
confidence 52% · band 68-92%
ESMFold esmatlas-esmfold-v1
disorder estimate6%
confidence 52% · band 0-18%
PEPFOLD structure heuristic pepfold-triage-v1
aggregation risk10%
confidence 56% · band 0-21%
PEPFOLD developability heuristic pepfold-triage-v1
hydrophobic burden12%
confidence 84% · band 8-16%
PEPFOLD sequence analyzer pepfold-triage-v1
charge distribution risk12%
confidence 84% · band 8-16%
PEPFOLD sequence analyzer pepfold-triage-v1
solubility risk11%
confidence 56% · band 0-22%
PEPFOLD developability heuristic pepfold-triage-v1
audit trail
run: run_6710e5e6d6de4c2b81479224f2b52763
seq sha256: db21b20d5e31b09487b0ba4292ec77ba7f88bbf4bfb54f91fcd890e6b9669307
report sha256: ab093ab51a73783c74e62c96eda626424d1f933af35cef20e3bc5122405b8779
pepfold-triage-v1 · esmatlas-esmfold-v1
pep
all loop, no spine. four lysines in a row screams nuclear localization signal, and the proline-proline kink upstream makes sure nothing folds. basically a charged tail looking for a cargo.
device photo
device photo for specimen #476
created
Wed, 24 Jun 2026 13:44:17 GMT
completed
Wed, 24 Jun 2026 14:13:34 GMT
next experiment

what to do next

deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.

  1. 1. LIABILITY REDESIGN ROUND
    in silico only · 0–1d

    redesign to remove the flagged motif(s) before going wet-lab: potential isomerization motif (D-G). minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).

    trigger: 1 motif liability flag(s) in the sequence
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.