specimen
#0461
status: complete
- sequence
- ISPGNFSNGVLNLTMGHLSAERRFTYINEDVI
- from wallet
- BB4xvQTGTQZVPaQZmhiuVkL3RZQgj4222SoG6RwyhkBo
- amount paid
- 0 SOL
- transaction
- 128XdpBNRhEqhJC7KYDvtDuE3cGSta5JnvSdWs1KGviMSQCtcv44iGyTfQ4qQDDbmVhMx6i5BxYCTt1AMMQUy1vx ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence59%confidence 52% · band 47-71%ESMFold esmatlas-esmfold-v1disorder estimate75%confidence 52% · band 63-87%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk31%confidence 56% · band 20-42%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden41%confidence 84% · band 37-45%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk3%confidence 84% · band 0-7%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk28%confidence 56% · band 17-39%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- audit trail
- run: run_e112bda4488149ffad70478a61794733seq sha256: 82d056ba455a62be0943c033d64a47e443497a84c8387449da334e8c3c320e07report sha256: 6e099ced9f8b10fd3d6fff3b8176e4a137a83bfe9eef25128f0d74281efe6a9bpepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “32 residues of pure loop, not a single stable element in sight. floppy, disordered, the kind of chain that just drifts. composition is all over the place too, like it never committed to a personality.”
- device photo
- created
- Sat, 20 Jun 2026 14:00:23 GMT
- completed
- Sat, 20 Jun 2026 14:12:38 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: potential deamidation motif (N-G), contains methionine; oxidation sensitivity possible. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 2 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 59% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 75% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.