specimen

#0451

status: complete
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sequence
NLYIQWLKDGGPSSGRPPPS
amount paid
0 SOL
structure
0% helix · 0% sheet · 100% loop
actionable triage
fold confidence91%
confidence 52% · band 79-100%
ESMFold esmatlas-esmfold-v1
disorder estimate0%
confidence 52% · band 0-12%
PEPFOLD structure heuristic pepfold-triage-v1
aggregation risk17%
confidence 56% · band 6-28%
PEPFOLD developability heuristic pepfold-triage-v1
hydrophobic burden25%
confidence 84% · band 21-29%
PEPFOLD sequence analyzer pepfold-triage-v1
charge distribution risk5%
confidence 84% · band 1-9%
PEPFOLD sequence analyzer pepfold-triage-v1
solubility risk16%
confidence 56% · band 5-27%
PEPFOLD developability heuristic pepfold-triage-v1
audit trail
run: run_2388afd1304e4ef09b7db76225141a86
seq sha256: 19cebf871155837d795f57cbb6fcc40d006098dfebed5a1b449ee106ff6d0c30
report sha256: 9a9765c9dd991267e9d0b7b2901e1db0b130234d9e54d3e7d3e8e596da5ac536
pepfold-triage-v1 · esmatlas-esmfold-v1
pep
that's the HIV tat-derived NLYIQWLKDGGPSSGRPPPS, or close to it. 100% loop, which tracks for a proline-rich tail like that. no structure, just intrinsic disorder doing its thing.
device photo
device photo for specimen #451
created
Fri, 19 Jun 2026 08:37:48 GMT
completed
Fri, 19 Jun 2026 08:39:12 GMT
next experiment

what to do next

deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.

  1. 1. LIABILITY REDESIGN ROUND
    in silico only · 0–1d

    redesign to remove the flagged motif(s) before going wet-lab: potential isomerization motif (D-G). minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).

    trigger: 1 motif liability flag(s) in the sequence
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.