specimen
#0447
status: complete
- sequence
- AALDAVQNAYKEYVLPTDQYNIFDDEIGPAADEEGYSQLMMRRAKEGEGGIGLMCPLPSSNQQ
- from wallet
- A2ahw7xcXfzJwDAzkz4vcpHaBR9zseViCr6Ps2GgjFJM
- amount paid
- 0 SOL
- transaction
- uae9ksquvN2S6yhdyeGiwL7EFJGJaDwL4yos32X4ezUtWLs9nm4cE7EcPm2N9MtrKqeHTdgo9TN2Uwe96v9rocK ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence54%confidence 52% · band 42-66%ESMFold esmatlas-esmfold-v1disorder estimate98%confidence 52% · band 86-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk34%confidence 56% · band 23-45%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden40%confidence 84% · band 36-44%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk11%confidence 84% · band 7-15%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk31%confidence 56% · band 20-42%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- synthesis hints
- - sequence length >45 aa may reduce synthesis yield
- audit trail
- run: run_e8b454e47448401aa6b8115588154181seq sha256: b16ac84c72730c378fd49b3cebbf79d27d7721792cc404d470337ad5243aa1d8report sha256: 16b6ccd273660c16265ff8ff0ccc13453b90f092f561cf7b8badcd92e824d5dapepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “63 residues and not a single helix or sheet, just pure loop from end to end. completely disordered, the kind of chain that flops around looking for a binding partner to give it shape. probably idr territory.”
- device photo
- created
- Thu, 18 Jun 2026 14:42:07 GMT
- completed
- Thu, 18 Jun 2026 14:52:08 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: contains methionine; oxidation sensitivity possible. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 1 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 54% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 98% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.