specimen
#0446
status: complete
- sequence
- DKLLWAINFDDTPVSDIATLALNRDESSVGIVHCRNENPDSDVLLNGEDLRL
- from wallet
- 9euVsSWvDLPNPVsRqc7qLwdMzApQzC4A8NnpjYpzUCoS
- amount paid
- 0 SOL
- transaction
- 4i3R3DcLugK6cw4UGKNAnAVCSNzwnxmEb6EJaMfJrApmvx3uKw1iHvgcKXnRpfFUWqnjeeqXBE3W4MX3XDSFJxEp ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence43%confidence 52% · band 31-55%ESMFold esmatlas-esmfold-v1disorder estimate100%confidence 52% · band 88-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk34%confidence 56% · band 23-45%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden39%confidence 84% · band 35-43%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk14%confidence 84% · band 10-18%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk31%confidence 56% · band 20-42%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- synthesis hints
- - sequence length >45 aa may reduce synthesis yield
- audit trail
- run: run_6ccc9b486b0f4005afbf6a0904634ab4seq sha256: 2bc466ab6f56a6221ece7231e55303c8b494a75e438d2b1490987fdf340d46ddreport sha256: 3fc02c21885f579e9533b12397d250ca3c6bdd21c1e7253853b37dbf6e94376bpepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “52 residues of pure loop. not a hint of secondary structure anywhere, just a long floppy chain doing whatever it wants. composition looks fine but nothing's committing to a fold. disappointing in a fascinating way.”
- device photo
- created
- Thu, 18 Jun 2026 14:41:38 GMT
- completed
- Thu, 18 Jun 2026 14:50:30 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: potential deamidation motif (N-G), long hydrophobic run may increase aggregation risk. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 2 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 43% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 100% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.