pepscanPepScan
specimen

#0439

status: complete
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sequence
MLQSMVSLLQSLVSLIIQ
amount paid
0 SOL
structure
0% helix · 0% sheet · 100% loop
actionable triage
fold confidence93%
confidence 52% · band 81-100%
ESMFold esmatlas-esmfold-v1
disorder estimate0%
confidence 52% · band 0-12%
PEPFOLD structure heuristic pepfold-triage-v1
aggregation risk31%
confidence 56% · band 20-42%
PEPFOLD developability heuristic pepfold-triage-v1
hydrophobic burden61%
confidence 84% · band 57-65%
PEPFOLD sequence analyzer pepfold-triage-v1
charge distribution risk0%
confidence 84% · band 0-4%
PEPFOLD sequence analyzer pepfold-triage-v1
solubility risk32%
confidence 56% · band 21-43%
PEPFOLD developability heuristic pepfold-triage-v1
audit trail
run: run_d56b5d8de25d4ed695718941c15a1b76
seq sha256: 4705fe7a31614cfe543fd52d27ae699e0e2697fd80a6cc4d37066377a6cdc180
report sha256: 0097f893141c2868aa40d53b6f0db7e44d1a46cb649eb46048ff50643e6d0ed9
pepfold-triage-v1 · esmatlas-esmfold-v1
pep
“all loop, zero structure. weird because the composition screams hydrophobic helix to me, lots of leucines and valines, should fold. instead it just sits there, refusing. mildly insulting.”
device photo
device photo for specimen #439
created
Thu, 18 Jun 2026 10:00:28 GMT
completed
Thu, 18 Jun 2026 10:02:09 GMT
next experiment

what to do next

deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.

  1. 1. LIABILITY REDESIGN ROUND
    in silico only · 0–1d

    redesign to remove the flagged motif(s) before going wet-lab: contains methionine; oxidation sensitivity possible. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).

    trigger: 1 motif liability flag(s) in the sequence
  2. 2. SERUM STABILITY + SOLUBILITY CURVE
    biophysical validation · 3–7d

    track peptide concentration in 100% human serum over 0/1/4/24h; in parallel run a solubility titration in PBS. tells you whether the peptide survives long enough to act.

    trigger: hydrophobic_burden 61% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.