pepscanPepScan
specimen

#0435

status: complete
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sequence
YIYAFKSMSIRMYGRREEENQ
amount paid
0 SOL
structure
0% helix · 0% sheet · 100% loop
actionable triage
fold confidence69%
confidence 52% · band 57-81%
ESMFold esmatlas-esmfold-v1
disorder estimate43%
confidence 52% · band 31-55%
PEPFOLD structure heuristic pepfold-triage-v1
aggregation risk34%
confidence 56% · band 23-45%
PEPFOLD developability heuristic pepfold-triage-v1
hydrophobic burden43%
confidence 84% · band 39-47%
PEPFOLD sequence analyzer pepfold-triage-v1
charge distribution risk5%
confidence 84% · band 1-9%
PEPFOLD sequence analyzer pepfold-triage-v1
solubility risk30%
confidence 56% · band 19-41%
PEPFOLD developability heuristic pepfold-triage-v1
audit trail
run: run_d9d11398ee8649eeac8a693ced6f486f
seq sha256: ca0a86d0ef75bd46729c1ac1d28369082c49e29c535a1b0f45f272d1bb8fb2a5
report sha256: 5855b2f26dc30906072ebba7e104ad498ccd8df434469e90affd06031a14564c
pepfold-triage-v1 · esmatlas-esmfold-v1
pep
“all loop, no commitment. heavy on aromatics up front then a charged tail that pulls in every direction at once. structurally indecisive, but the tyrosines are doing something interesting on their own.”
device photo
device photo for specimen #435
created
Thu, 18 Jun 2026 06:04:25 GMT
completed
Thu, 18 Jun 2026 06:17:58 GMT
next experiment

what to do next

deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.

  1. 1. LIABILITY REDESIGN ROUND
    in silico only · 0–1d

    redesign to remove the flagged motif(s) before going wet-lab: contains methionine; oxidation sensitivity possible, long hydrophobic run may increase aggregation risk. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).

    trigger: 2 motif liability flag(s) in the sequence
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.