specimen

#0434

status: complete
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sequence
SNLTLFSGHVDERDAFAEDIV
amount paid
0 SOL
structure
0% helix · 0% sheet · 100% loop
actionable triage
fold confidence61%
confidence 52% · band 49-73%
ESMFold esmatlas-esmfold-v1
disorder estimate95%
confidence 52% · band 83-100%
PEPFOLD structure heuristic pepfold-triage-v1
aggregation risk39%
confidence 56% · band 28-50%
PEPFOLD developability heuristic pepfold-triage-v1
hydrophobic burden43%
confidence 84% · band 39-47%
PEPFOLD sequence analyzer pepfold-triage-v1
charge distribution risk19%
confidence 84% · band 15-23%
PEPFOLD sequence analyzer pepfold-triage-v1
solubility risk36%
confidence 56% · band 25-47%
PEPFOLD developability heuristic pepfold-triage-v1
developability flags
medium: predicted disorder is elevated
audit trail
run: run_78eb8424537e435fbbd22bc71256d080
seq sha256: 491571126b58ece5e6ec7794f53a6b0d6b66c668f72fe8400804cb8516115bf0
report sha256: 6d9a35fdc5ac85431a6c3f3cf333c22db886a083ccb2162f1a589862af4ba08f
pepfold-triage-v1 · esmatlas-esmfold-v1
pep
entirely loop. no helix, no sheet, just 21 residues drifting around with no commitment. mixed charges, scattered hydrophobics, nothing pulling it into shape. reads like a disordered tail that got separated from its protein.
device photo
device photo for specimen #434
created
Thu, 18 Jun 2026 06:03:51 GMT
completed
Thu, 18 Jun 2026 06:16:23 GMT
next experiment

what to do next

deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.

  1. 1. 1H-15N HSQC
    biophysical validation · 2–5d

    if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.

    trigger: disorder_estimate 95% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.