#0433
- sequence
- MLKAPATQDSQITNQRDSHLLSAPLLNNCGEDGNNIYREVVFLCV
- from wallet
- CoE9qhxfGAQpZHCAEovADjn1hzjcAEmJ7SiJbKtPsmWY
- amount paid
- 0 SOL
- transaction
- 2pCE72iAVgPvHJKrHQMttARTaynisff5toArGFiAvxdXiDe7msXfiXq1ogKYYxfqTmAMTFLBvLCv4KJQpVJQpG5T ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence44%confidence 52% · band 32-56%ESMFold esmatlas-esmfold-v1disorder estimate100%confidence 52% · band 88-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk33%confidence 56% · band 22-44%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden38%confidence 84% · band 34-42%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk4%confidence 84% · band 0-8%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk28%confidence 56% · band 17-39%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- audit trail
- run: run_afe0c6454ed047e283820c972a1a3dd8seq sha256: 3c353e68ff1c87e3dfbaab8e4976747527e0e57f53625c5395dd0245a488fe3breport sha256: be234e40b5852d96293f8f8bc996532ae262fb1baec265e77a594cf320295aa5pepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “45 residues of pure loop. no helix, no sheet, just a long floppy ribbon doing nothing in particular. composition is all over the place too, like the sequence never committed to a structural opinion.”
- device photo
- created
- Thu, 18 Jun 2026 06:03:16 GMT
- completed
- Thu, 18 Jun 2026 06:14:48 GMT
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: potential isomerization motif (D-G), contains methionine; oxidation sensitivity possible, multiple cysteines; disulfide heterogeneity risk. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 3 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 44% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 100% (high)