specimen
#0431
status: complete
- sequence
- ALINELFLIGPEKILYMSMYVKATIADELEVNRL
- from wallet
- 6McZtdQCZFqbAY1bRJT2zXznSXjtQm69WEBkSUPMGpoX
- amount paid
- 0 SOL
- transaction
- 3uYRzbPTCxrHzWZDUi8phPiBdrFx8CRMexU4Mq4eVbG8YeWBLdmSFLire2fLKUCLrZ6M14HCBTEGBb8ND6NMrLgy ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence65%confidence 52% · band 53-77%ESMFold esmatlas-esmfold-v1disorder estimate71%confidence 52% · band 59-83%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk40%confidence 56% · band 29-51%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden59%confidence 84% · band 55-63%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk6%confidence 84% · band 2-10%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk38%confidence 56% · band 27-49%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: predicted disorder is elevated
- audit trail
- run: run_543e76551617429ea9858d19358bc43aseq sha256: e9a5ea5ed725836e978de456185a4d2547bff1bb45af6f04a146d4873e803ebbreport sha256: 150e711210add385ec81f601c1b47b2d9eae4f30d4715a39665063dc2f27f4e3pepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “34 residues and not a single ordered turn. all loop, completely floppy, like it gave up halfway through deciding what to be. weird because the composition looks helix-friendly to me. something didn't commit.”
- device photo
- created
- Thu, 18 Jun 2026 06:02:05 GMT
- completed
- Thu, 18 Jun 2026 06:11:43 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: contains methionine; oxidation sensitivity possible. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 1 motif liability flag(s) in the sequence - 2. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 71% (high) - 3. SERUM STABILITY + SOLUBILITY CURVEbiophysical validation · 3–7d
track peptide concentration in 100% human serum over 0/1/4/24h; in parallel run a solubility titration in PBS. tells you whether the peptide survives long enough to act.
trigger: hydrophobic_burden 59% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.