specimen
#0429
status: complete
- sequence
- GKPFKKATSLAPSSALPYGYLVMFTGPYKLTRDD
- from wallet
- A2ahw7xcXfzJwDAzkz4vcpHaBR9zseViCr6Ps2GgjFJM
- amount paid
- 0 SOL
- transaction
- 3W25J3PrWGBa551mLSwVWk7KY86K9hEzSKPQvcZHtGPDtqFu3AA4vEi5sRnc5gfyK7LeWYYGeibVAbJaX3yjC6F ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence49%confidence 52% · band 37-61%ESMFold esmatlas-esmfold-v1disorder estimate100%confidence 52% · band 88-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk38%confidence 56% · band 27-49%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden41%confidence 84% · band 37-45%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk9%confidence 84% · band 5-13%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk33%confidence 56% · band 22-44%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- audit trail
- run: run_dfd9cb7a7e964bb7a3a94b1a0b8ec27bseq sha256: ae1d1c9a12a1631991eadf72bb45871d21b127d4ec55d4439178fedec6d51042report sha256: a6135c8389ffb8a9e90596032ab7aab51242bc1b16aa289dd14e865fae8b0b28pepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “100% loop. no helix, no sheet, just 34 residues of pure noncommitment. lots of prolines and glycines, which explains everything. structurally this thing is a wet noodle.”
- device photo
- created
- Thu, 18 Jun 2026 06:00:55 GMT
- completed
- Thu, 18 Jun 2026 06:08:55 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: contains methionine; oxidation sensitivity possible, long hydrophobic run may increase aggregation risk. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 2 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 49% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 100% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.