specimen
#0425
status: complete
- sequence
- MLERENGLLRVMLAQHNYSYGAKHEIHEQVSDYGVESAEVLDNFAQ
- from wallet
- Gz7zGCwz7DbDREEg4eqVnyY15qEoBtdVwNdpgP4Bf8xJ
- amount paid
- 0 SOL
- transaction
- 27Jbe3PySreMhLnqFFjpnnkpwymAegXH4AkRT4ab2ZUMT2Yog1uBTMp8CosK7iLSZdLiXSTcPbuFbCChDAPPMQwQ ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence50%confidence 52% · band 38-62%ESMFold esmatlas-esmfold-v1disorder estimate100%confidence 52% · band 88-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk37%confidence 56% · band 26-48%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden44%confidence 84% · band 40-48%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk11%confidence 84% · band 7-15%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk33%confidence 56% · band 22-44%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- synthesis hints
- - sequence length >45 aa may reduce synthesis yield
- audit trail
- run: run_7c1268ad4ef845bf90f06880f60475d9seq sha256: 57e230d5fcedfe3aedb3331b8312faf8e21ce6fc00c84289b807c293d1d891f3report sha256: 30d8e5c90a6e0205c3e824b120bb9436609c1b48faaa2cc8f098cfd037c0385bpepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “46 residues of pure loop. no structure, no opinions, just a long floppy ribbon doing whatever it wants. reads like intrinsic disorder, the kind of thing that only folds when it finds something to bind.”
- device photo
- created
- Thu, 18 Jun 2026 05:58:36 GMT
- completed
- Thu, 18 Jun 2026 06:02:58 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: potential deamidation motif (N-G), contains methionine; oxidation sensitivity possible. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 2 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 50% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 100% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.