pepscanPepScan
specimen

#0423

status: complete
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sequence
QLTRSMGAVIGDNEVYTPTLHLASVARALGAAGIMKELMHVLAPCPNVVGALGVGGVHLLP
amount paid
0 SOL
structure
0% helix · 0% sheet · 100% loop
actionable triage
fold confidence49%
confidence 52% · band 37-61%
ESMFold esmatlas-esmfold-v1
disorder estimate100%
confidence 52% · band 88-100%
PEPFOLD structure heuristic pepfold-triage-v1
aggregation risk37%
confidence 56% · band 26-48%
PEPFOLD developability heuristic pepfold-triage-v1
hydrophobic burden51%
confidence 84% · band 47-55%
PEPFOLD sequence analyzer pepfold-triage-v1
charge distribution risk0%
confidence 84% · band 0-4%
PEPFOLD sequence analyzer pepfold-triage-v1
solubility risk32%
confidence 56% · band 21-43%
PEPFOLD developability heuristic pepfold-triage-v1
developability flags
medium: structure confidence is limited
medium: predicted disorder is elevated
synthesis hints
  • - sequence length >45 aa may reduce synthesis yield
audit trail
run: run_309db716525a4f05af121404533b5f3b
seq sha256: 51cb2223aee0a70088c4c26d7f4d4b576e1be8acbd7adbe350328dbcf857f89d
report sha256: 0e8fdb05eadc3e2eb6b140f5f8d2fc60b06eeb6a6d61d40d2ed88196485f8929
pepfold-triage-v1 · esmatlas-esmfold-v1
pep
“61 residues of pure loop. no helix, no sheet, just vibes. unusual given the leucine and valine content, you'd expect something to collapse into a helix, but it just sprawls.”
device photo
device photo for specimen #423
created
Thu, 18 Jun 2026 05:57:27 GMT
completed
Thu, 18 Jun 2026 05:59:42 GMT
next experiment

what to do next

deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.

  1. 1. LIABILITY REDESIGN ROUND
    in silico only · 0–1d

    redesign to remove the flagged motif(s) before going wet-lab: contains methionine; oxidation sensitivity possible. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).

    trigger: 1 motif liability flag(s) in the sequence
  2. 2. CD SPECTROSCOPY
    biophysical validation · 1–3d

    experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.

    trigger: fold_confidence 49% (model is uncertain)
  3. 3. 1H-15N HSQC
    biophysical validation · 2–5d

    if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.

    trigger: disorder_estimate 100% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.