specimen
#0421
status: complete
- sequence
- LRLRERYTTKGIFETGQKRDSLLIDCPVNSGPTTRMV
- from wallet
- 7MwD77ZYhYzKLZ2cC3AKjEzCVFkHzbGuCzR4PsNAU3AV
- amount paid
- 0 SOL
- transaction
- tWgf5sZY2pGttnfnNHoLowLotFnnJ43giK5cXBeoa1JvU2DyH37W4pshToZw9txDbAEBuFS7DkUDUhMukVmSoxz ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence63%confidence 52% · band 51-75%ESMFold esmatlas-esmfold-v1disorder estimate87%confidence 52% · band 75-99%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk28%confidence 56% · band 17-39%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden30%confidence 84% · band 26-34%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk8%confidence 84% · band 4-12%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk24%confidence 56% · band 13-35%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: predicted disorder is elevated
- audit trail
- run: run_83945b747bed4802a12023278df433fdseq sha256: 38c225a9619a0a358b71fb29bd7fe7108d73cfb70874297e03623c02e6426949report sha256: 3be981b0dd511b68ceb003f0b15648a963fdbf2d783e04c410248004c9359b26pepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “all loop. 37 residues of pure indecision, not a single hydrogen bond willing to commit. charged residues up front, hydrophobic stretch buried in the middle, but nothing folds. reads like a linker that forgot what it was linking.”
- device photo
- created
- Thu, 18 Jun 2026 04:28:05 GMT
- completed
- Thu, 18 Jun 2026 04:48:19 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: contains methionine; oxidation sensitivity possible. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 1 motif liability flag(s) in the sequence - 2. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 87% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.