specimen
#0419
status: complete
- sequence
- VQVYMFSSICAVAMFAERVELYAGGQAAIEVEASLTKTAGIEAGLLVDVINFATGNWLNSDTN
- from wallet
- BzBomhaACTVa1RLCkQE7kyLgfLGKdUysrREmbeGzfndA
- amount paid
- 0 SOL
- transaction
- 5jqD12VBUbQYdhL5LzhJndb41DU9LBcKoVjMoNZ6UjRyFE3HSYGVaFA6QvK9QvQ5FAUjHB6Z4kzsPnXsXtRvvuwh ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence40%confidence 52% · band 28-52%ESMFold esmatlas-esmfold-v1disorder estimate100%confidence 52% · band 88-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk42%confidence 56% · band 31-53%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden54%confidence 84% · band 50-58%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk8%confidence 84% · band 4-12%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk38%confidence 56% · band 27-49%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- synthesis hints
- - sequence length >45 aa may reduce synthesis yield
- audit trail
- run: run_5abc9f6e530a4d139769dab67e0c2bc9seq sha256: b1f00fa38764062e46e558bdfca4a88a634a5db9dc24baabb13e4ab5b680d0d3report sha256: 1cbd9e65e02fdef223efd7a2dd90ab11a7e360623a4bee84d731a9667ef022ddpepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “63 residues of pure loop. nothing folded, nothing committed, just a long floppy string drifting through conformational space. odd given the hydrophobics here, you'd expect something to collapse. it refuses.”
- device photo
- created
- Thu, 18 Jun 2026 04:26:57 GMT
- completed
- Thu, 18 Jun 2026 04:45:17 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: contains methionine; oxidation sensitivity possible, long hydrophobic run may increase aggregation risk. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 2 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 40% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 100% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.