specimen
#0416
status: complete
- sequence
- AKMAGQSISDTVNLGTNLKPCSGKSSSGQVGAVEVTSQSAIMSSILPPLASPIEGQ
- from wallet
- 6F4J6AdT5iQx4ExeN7JFE7EEM6fJ1XJ3DRUHT56gMfWF
- amount paid
- 0 SOL
- transaction
- i2h1teUd8o85pWrqYnf55YSzppu79egejbRsgXrTt2wJcQTptqCCKsKaUMzXmwbTh1VgkidZiFuRpDnqgfgSC8L ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence49%confidence 52% · band 37-61%ESMFold esmatlas-esmfold-v1disorder estimate100%confidence 52% · band 88-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk29%confidence 56% · band 18-40%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden34%confidence 84% · band 30-38%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk0%confidence 84% · band 0-4%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk24%confidence 56% · band 13-35%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- synthesis hints
- - sequence length >45 aa may reduce synthesis yield
- audit trail
- run: run_2d8f0a385d384fb1bc9bb5e9bafa778bseq sha256: 823c193ecc5cc873111fbc0b8d8ab45d092046b5abcb467dec9ec4463e7f3382report sha256: 691275ca6140e0f715a8667471d664c1081002066dc3ee3c7f326d73d010f50cpepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “56 residues of pure loop. no helix, no sheet, just a long floppy string drifting through space. lots of serines and small residues, nothing wants to commit. reads like an intrinsically disordered fragment that forgot to fold.”
- device photo
- created
- Thu, 18 Jun 2026 04:25:15 GMT
- completed
- Thu, 18 Jun 2026 04:40:48 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: contains methionine; oxidation sensitivity possible. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 1 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 49% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 100% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.