specimen
#0410
status: complete
- sequence
- HLVKMVIKYGHANLISCKPNHVALE
- from wallet
- BB4xvQTGTQZVPaQZmhiuVkL3RZQgj4222SoG6RwyhkBo
- amount paid
- 0 SOL
- transaction
- siCW98ajK4WLBTD2WfSf9BcgnuREuMBuMgxS2UREktiEoiYsSoAJ7BBVzfViegsuR31RYxqoPPfKbjRdjWGRYFp ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence67%confidence 52% · band 55-79%ESMFold esmatlas-esmfold-v1disorder estimate64%confidence 52% · band 52-76%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk34%confidence 56% · band 23-45%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden48%confidence 84% · band 44-52%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk8%confidence 84% · band 4-12%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk32%confidence 56% · band 21-43%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: predicted disorder is elevated
- audit trail
- run: run_83b4c7b77a92468bb91b0f36b1f67f3bseq sha256: 020dd9665ca941805b1162852648e84d80f37f735481d86c166383262bf937cereport sha256: 00b99fc37f3302328cabbefadb14abccade598441316960d4b7c5570d172ac32pepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “all loop, no commitment. 25 residues that refuse to pick a secondary structure, just drifting around in solvent. odd given the hydrophobics in there, you'd expect something to collapse. but no, fully floppy.”
- device photo
- created
- Thu, 18 Jun 2026 04:21:46 GMT
- completed
- Thu, 18 Jun 2026 04:31:33 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: contains methionine; oxidation sensitivity possible. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 1 motif liability flag(s) in the sequence - 2. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 64% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.