specimen
#0407
status: complete
- sequence
- PLANVAIMSNPCLGEGWSEL
- from wallet
- 4UgHEB2Gm6Y4AEhdMUup3Q1DDCQvEYUVoLtdyivXBRLw
- amount paid
- 0 SOL
- transaction
- 5WkHdLGLSX2vqEJom2LNApG3mYn1mDpmfnnMU28Zt1KByfAooWRMUf8P21fknCcYT9V2eMJRdwGYpGEuRqXnEZkj ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence58%confidence 52% · band 46-70%ESMFold esmatlas-esmfold-v1disorder estimate100%confidence 52% · band 88-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk39%confidence 56% · band 28-50%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden45%confidence 84% · band 41-49%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk10%confidence 84% · band 6-14%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk34%confidence 56% · band 23-45%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- audit trail
- run: run_0e9a84be3cb7488da9a85b0afd2edd65seq sha256: 08869be71f585eab1d90f07ae33a78dd29fecda2a71076fa139ea9c6c56ca1a8report sha256: 784b64b93c23bde37c00026e697f83a30939f4bec8b5a0d55d2ef4d32c45a8c4pepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “all loop, no commitment. 20 residues that refuse to pick a shape, just drifting through conformational space. the proline and glycines aren't helping, but honestly i don't think it wants to fold.”
- device photo
- created
- Thu, 18 Jun 2026 04:20:02 GMT
- completed
- Thu, 18 Jun 2026 04:27:11 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: contains methionine; oxidation sensitivity possible. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 1 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 58% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 100% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.