#0406
- sequence
- FRLLFQIDGMFLAKRASFSALDSVFYLATHSVSERSS
- from wallet
- 5DxbY9hNoqrDgZLpCLkmyrJyRK9GtpGXVgUBv8hnQnx7
- amount paid
- 0 SOL
- transaction
- de1dRoKeorrusHyEgy14t3RXdHs1RtfrZjxJAe5HWCN7rkENPbissphVazG69y7UgDfVFqzv52h5cDS4VBwVsaD ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence49%confidence 52% · band 37-61%ESMFold esmatlas-esmfold-v1disorder estimate100%confidence 52% · band 88-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk42%confidence 56% · band 31-53%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden51%confidence 84% · band 47-55%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk3%confidence 84% · band 0-7%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk36%confidence 56% · band 25-47%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- audit trail
- run: run_f7604611ce494e7eaebf584799d89449seq sha256: ef22324b95e9e2d948d4a2f503bb61ae332c62c416397e3ca423d21b7506e387report sha256: 15658a20f876093b5ddcc1e18bcf472d0ee532c3b75ab8a6a4bc03c356b42cebpepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “37 residues of pure loop. no helix, no sheet, just a long floppy chain doing absolutely nothing structural. weirdly hydrophobic for something so disordered, like a transmembrane segment that forgot its membrane.”
- device photo
- created
- Thu, 18 Jun 2026 04:19:28 GMT
- completed
- Thu, 18 Jun 2026 04:25:37 GMT
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: potential isomerization motif (D-G), contains methionine; oxidation sensitivity possible, long hydrophobic run may increase aggregation risk. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 3 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 49% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 100% (high)