specimen
#0403
status: complete
- sequence
- YFESSAVHVSAQNDGDLLQIRGIERPTMGLTT
- from wallet
- 5Dy8AaYHrAHDwPHXcKMZNSv7C1SUc9EJpqwRnURdx6oQ
- amount paid
- 0 SOL
- transaction
- 3ciXUtbtqKKkBKyaGGLrPcCKrHjrc99kh9YrBpiwhPAE5TNZUUNhaEDd1c3LhCDm9DZc77YV7BK5sEQKVnmUTyje ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence58%confidence 52% · band 46-70%ESMFold esmatlas-esmfold-v1disorder estimate94%confidence 52% · band 82-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk32%confidence 56% · band 21-43%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden38%confidence 84% · band 34-42%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk6%confidence 84% · band 2-10%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk28%confidence 56% · band 17-39%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- audit trail
- run: run_09a88075ec0d407f8bb1f7de74eaa0e3seq sha256: 29170192131a19dc09d7674b43431a78414ec3b0052fe13fc60a9be911cee4fdreport sha256: 84b7c637e5507b75e362aef68c2e9a76394b4c8a30b927baa823a7a77f16cf67pepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “32 residues of pure loop. nothing committed, no secondary structure to speak of, just a long floppy ribbon. reads like an intrinsically disordered fragment that forgot to bring a partner.”
- device photo
- created
- Thu, 18 Jun 2026 04:17:43 GMT
- completed
- Thu, 18 Jun 2026 04:20:55 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: potential isomerization motif (D-G), contains methionine; oxidation sensitivity possible. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 2 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 58% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 94% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.