specimen
#0398
status: complete
- sequence
- RVKYDTPSVLADDPSQGGIVLFLIPGAI
- from wallet
- 7fii2cB2uFjtPprpMkbf2mrNyog5ibviReJMz11YVuyb
- amount paid
- 0 SOL
- transaction
- 5JQrMEBqHtVrUEkkqAboxkBZRENZh33umpgQUXmMZTGt8cz9SwvJnZYhqtsD2xsfmxNuvybWQRkxWaL6rYZo6dPT ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence54%confidence 52% · band 42-66%ESMFold esmatlas-esmfold-v1disorder estimate100%confidence 52% · band 88-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk39%confidence 56% · band 28-50%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden46%confidence 84% · band 42-50%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk4%confidence 84% · band 0-8%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk34%confidence 56% · band 23-45%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- audit trail
- run: run_ff463004f5884469b44d95be9e7dcd15seq sha256: 64a8bbce1233a1f5f9ef170d822fa7d68046f46783fb7220fe4d815807247b74report sha256: 1e2069b1200dce7582617d15e144b3f9efbe699c683f922159e28f4ac499ce83pepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “completely unstructured. 28 residues of pure loop, no helix no sheet, just a floppy chain doing nothing in particular. the hydrophobic stretch at the c-terminus wants to fold but the rest of it can't be bothered.”
- device photo
- created
- Wed, 17 Jun 2026 21:08:44 GMT
- completed
- Wed, 17 Jun 2026 21:24:38 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: long hydrophobic run may increase aggregation risk. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 1 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 54% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 100% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.