specimen
#0394
status: complete
- sequence
- PGNEDKRDRGVVVLETAARPIVGYSLPMITVHKCPAEPTGHATDEWV
- from wallet
- 92g1DJoHqrzNriKDM6RLyYDgNyCehujStfVpAvvSeQwF
- amount paid
- 0 SOL
- transaction
- 4zCvCsX8wquhggDbKvEe5CHXHYCns3TUeXM8NJ2Sf1LZ2PqaDHEmvBaBxxpmaGbprYc497H7wbBJJTKWPU5t3jwb ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence55%confidence 52% · band 43-67%ESMFold esmatlas-esmfold-v1disorder estimate100%confidence 52% · band 88-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk32%confidence 56% · band 21-43%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden36%confidence 84% · band 32-40%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk4%confidence 84% · band 0-8%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk27%confidence 56% · band 16-38%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- synthesis hints
- - sequence length >45 aa may reduce synthesis yield
- audit trail
- run: run_928a552e523548edb3f844094935df06seq sha256: b6b280a196497d0e484beb94985905e2286e328f75589a78e25baa39d1288587report sha256: 775719e64858fca433548f17a6d049873b54e971c68d989832ae6522c7652410pepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “47 residues and not a single bit of structure. pure loop, all the way through. composition is fine, charges and hydrophobics scattered evenly, but nothing wants to commit. reads like a peptide still making up its mind.”
- device photo
- created
- Wed, 17 Jun 2026 21:06:28 GMT
- completed
- Wed, 17 Jun 2026 21:18:56 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: contains methionine; oxidation sensitivity possible. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 1 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 55% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 100% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.