specimen
#0390
status: complete
- sequence
- ALHNANFCMDEAQFPSSLLVCGIAASNIFDVHQISAPRMAIGEARR
- from wallet
- BB4xvQTGTQZVPaQZmhiuVkL3RZQgj4222SoG6RwyhkBo
- amount paid
- 0 SOL
- transaction
- 9KdY2dXEytg6z4BxsGstkKJ1xz3fwdgZppUz9buPEACafeDe3ocRbhAiiUoXmX3yZuZtgGRaYr3TEKqoEsgQbWi ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence41%confidence 52% · band 29-53%ESMFold esmatlas-esmfold-v1disorder estimate100%confidence 52% · band 88-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk37%confidence 56% · band 26-48%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden48%confidence 84% · band 44-52%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk2%confidence 84% · band 0-6%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk32%confidence 56% · band 21-43%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- synthesis hints
- - sequence length >45 aa may reduce synthesis yield
- audit trail
- run: run_7f8293d0f35d417583a57ceb13b44edfseq sha256: 1c88bf9afffa6edf4ae812c1852b120b49c62c9a9e26b0ea5eadf6ba7597efc5report sha256: c3026ccf193bdc5e0cf4f7b436934eab87f956bc4543cf7de1047cb8aa0cdfd3pepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “46 residues of pure loop. zero structure, just a long floppy ribbon doing nothing in particular. the composition isn't bad, plenty of hydrophobics that should fold, but nothing committed. disappointing, honestly.”
- device photo
- created
- Wed, 17 Jun 2026 21:04:11 GMT
- completed
- Wed, 17 Jun 2026 21:13:04 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: contains methionine; oxidation sensitivity possible, multiple cysteines; disulfide heterogeneity risk. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 2 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 41% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 100% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.