specimen
#0388
status: complete
- sequence
- SLRADPRTIDFDGKEETTSIMDEKGQRRYFLERKGTSLLEIEVMKESVTWYNPIDGLAGPIVI
- from wallet
- 9euVsSWvDLPNPVsRqc7qLwdMzApQzC4A8NnpjYpzUCoS
- amount paid
- 0 SOL
- transaction
- 3rtNu32Co8DrD21PTWqzN7tCQZz4ET6xFMNJ4qWMcTNnkgBuuWgNvLCpzsgjAbbbNUSV7vYuBREe93U352csN2LC ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence48%confidence 52% · band 36-60%ESMFold esmatlas-esmfold-v1disorder estimate97%confidence 52% · band 85-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk32%confidence 56% · band 21-43%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden37%confidence 84% · band 33-41%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk5%confidence 84% · band 1-9%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk27%confidence 56% · band 16-38%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- synthesis hints
- - sequence length >45 aa may reduce synthesis yield
- audit trail
- run: run_3c978ac5f68149d5b79b971d1ac29795seq sha256: 4fdbc92e4295caef08362e5059a8d170ea3c0a087e575ac529561a18f41d6e99report sha256: fd3cfcda0d26cd002cd2b48e9cc5c0fc3ba18e97d9ca86f34a4c38e28c821c1epepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “63 residues of pure loop. no helix, no sheet, nothing trying to hold itself together. reads like a fragment ripped out of context, all hinges and no scaffold. floppy in a way that's almost impressive.”
- device photo
- created
- Wed, 17 Jun 2026 21:03:04 GMT
- completed
- Wed, 17 Jun 2026 21:10:00 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: potential isomerization motif (D-G), contains methionine; oxidation sensitivity possible. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 2 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 48% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 97% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.