pepscanPepScan
specimen

#0375

status: complete
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sequence
VVVLLLIIIAAAFGGVLILA
amount paid
0 SOL
structure
0% helix · 0% sheet · 100% loop
actionable triage
fold confidence87%
confidence 52% · band 75-99%
ESMFold esmatlas-esmfold-v1
disorder estimate0%
confidence 52% · band 0-12%
PEPFOLD structure heuristic pepfold-triage-v1
aggregation risk54%
confidence 56% · band 43-65%
PEPFOLD developability heuristic pepfold-triage-v1
hydrophobic burden90%
confidence 84% · band 86-94%
PEPFOLD sequence analyzer pepfold-triage-v1
charge distribution risk0%
confidence 84% · band 0-4%
PEPFOLD sequence analyzer pepfold-triage-v1
solubility risk51%
confidence 56% · band 40-62%
PEPFOLD developability heuristic pepfold-triage-v1
audit trail
run: run_ed249af2665c4ea9b02b15c346cdd5c0
seq sha256: 358369e033d0ae4373704f4e39d96337bba6624492ff2f56f3d486df69526ae8
report sha256: 55a5635ca6986fc12ac90a1eead177d90d4cb44d8446fc69eec0cbb9423f788a
pepfold-triage-v1 · esmatlas-esmfold-v1
pep
“pure hydrophobic sludge. valines, leucines, isoleucines, alanines, not a charged residue in sight. predicted all loop but in reality this thing would just collapse into a greasy blob or embed itself in a membrane and never come out.”
device photo
device photo for specimen #375
created
Wed, 17 Jun 2026 20:03:36 GMT
completed
Wed, 17 Jun 2026 20:19:15 GMT
next experiment

what to do next

deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.

  1. 1. LIABILITY REDESIGN ROUND
    in silico only · 0–1d

    redesign to remove the flagged motif(s) before going wet-lab: long hydrophobic run may increase aggregation risk. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).

    trigger: 1 motif liability flag(s) in the sequence
  2. 2. SERUM STABILITY + SOLUBILITY CURVE
    biophysical validation · 3–7d

    track peptide concentration in 100% human serum over 0/1/4/24h; in parallel run a solubility titration in PBS. tells you whether the peptide survives long enough to act.

    trigger: hydrophobic_burden 90% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.