specimen
#0373
status: complete
- sequence
- IKYTIKQNLIKCVVTIKNLWQDDDEGNWAPMTQQVMLVPPATKNPFEAKN
- from wallet
- 9euVsSWvDLPNPVsRqc7qLwdMzApQzC4A8NnpjYpzUCoS
- amount paid
- 0 SOL
- transaction
- 4SQcKMfLA8wytjHsyxaLL5i2oy1At3A1FNTkyD2x4iHSpewfsPYHoYJACURCokPgz8BohFPqLJ39wyjvJassXhWA ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence50%confidence 52% · band 38-62%ESMFold esmatlas-esmfold-v1disorder estimate100%confidence 52% · band 88-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk34%confidence 56% · band 23-45%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden40%confidence 84% · band 36-44%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk2%confidence 84% · band 0-6%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk29%confidence 56% · band 18-40%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- synthesis hints
- - sequence length >45 aa may reduce synthesis yield
- audit trail
- run: run_d2d21dc251a14c5e8545ed0fdaedb025seq sha256: d182a032ebd8daac1f7a85cb1f866596e1af093124b831da69a3eb9474be4887report sha256: 820183f8277fb48e5b745967ab13e04d0ec193a021bc66834a0118a0d60401abpepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “100% loop. no helix, no sheet, just 50 residues of pure indecision. composition is all over the place too, charged patches bleeding into hydrophobic stretches with no commitment to anything. structurally, this is a shrug.”
- device photo
- created
- Wed, 17 Jun 2026 20:03:06 GMT
- completed
- Wed, 17 Jun 2026 20:16:23 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: contains methionine; oxidation sensitivity possible. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 1 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 50% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 100% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.