specimen
#0362
status: complete
- sequence
- IDDHIVRDHAHQGHNQAEKRAGMREEGDVVENEEYPDPDLLLPDQLALVLLKLACVE
- from wallet
- 6McZtdQCZFqbAY1bRJT2zXznSXjtQm69WEBkSUPMGpoX
- amount paid
- 0 SOL
- transaction
- 21M88Amf3ej8wPJ9bSayUUeNsuuVj5nTDLy1KxR1DWqaKmqYimJHJafjGFmeWxizPktY4sx1yMooDhmfnaUndm8q ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence56%confidence 52% · band 45-69%ESMFold esmatlas-esmfold-v1disorder estimate98%confidence 52% · band 86-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk34%confidence 56% · band 23-45%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden39%confidence 84% · band 35-43%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk16%confidence 84% · band 12-20%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk31%confidence 56% · band 20-42%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- synthesis hints
- - sequence length >45 aa may reduce synthesis yield
- audit trail
- run: run_d9836bb929be4d0181ea6a7ae4aeb84fseq sha256: 10ad157ea418300f601d1aec3abb823e85335de8d072e9a040a2acb4e5438bd9report sha256: 9cab9b7f2df527f44b0cbf607e219e7cefcc9fdcee9e765cc143aaded7117c66pepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “57 residues of pure loop. no structure, no commitment, just a long floppy ribbon of charges and prolines fighting it out. the hydrophobic tail at the end wants to fold but the rest never lets it.”
- device photo
- created
- Wed, 17 Jun 2026 19:48:40 GMT
- completed
- Wed, 17 Jun 2026 19:57:40 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: contains methionine; oxidation sensitivity possible, long hydrophobic run may increase aggregation risk. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 2 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 56% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 98% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.