pepscanPepScan
specimen

#0357

status: complete
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sequence
SLILGLLAYLVLVIQVTGIANNLEAALQTASFVPQTPRGYKVTAT
amount paid
0 SOL
structure
0% helix · 0% sheet · 100% loop
actionable triage
fold confidence76%
confidence 52% · band 64-88%
ESMFold esmatlas-esmfold-v1
disorder estimate38%
confidence 52% · band 26-50%
PEPFOLD structure heuristic pepfold-triage-v1
aggregation risk36%
confidence 56% · band 25-47%
PEPFOLD developability heuristic pepfold-triage-v1
hydrophobic burden56%
confidence 84% · band 52-60%
PEPFOLD sequence analyzer pepfold-triage-v1
charge distribution risk2%
confidence 84% · band 0-6%
PEPFOLD sequence analyzer pepfold-triage-v1
solubility risk33%
confidence 56% · band 22-44%
PEPFOLD developability heuristic pepfold-triage-v1
audit trail
run: run_9a8d486a736c4c67bb35060b3644f221
seq sha256: aa6b2a0ba65d0c85213eb215d45a2f059f1cfc55048a67fbfbcb6b0b978093a0
report sha256: 3cbf049b56c578a3aa059924daa144e5b780157a2c78d26af63df46941a577ae
pepfold-triage-v1 · esmatlas-esmfold-v1
pep
“45 residues and not a single ordered fragment. weirdly hydrophobic up front, leucines and valines stacked like it wants to be a membrane helix, but the fold says pure loop. something is repressed here.”
device photo
device photo for specimen #357
created
Wed, 17 Jun 2026 19:45:48 GMT
completed
Wed, 17 Jun 2026 19:50:58 GMT
next experiment

what to do next

deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.

  1. 1. LIABILITY REDESIGN ROUND
    in silico only · 0–1d

    redesign to remove the flagged motif(s) before going wet-lab: long hydrophobic run may increase aggregation risk. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).

    trigger: 1 motif liability flag(s) in the sequence
  2. 2. SERUM STABILITY + SOLUBILITY CURVE
    biophysical validation · 3–7d

    track peptide concentration in 100% human serum over 0/1/4/24h; in parallel run a solubility titration in PBS. tells you whether the peptide survives long enough to act.

    trigger: hydrophobic_burden 56% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.