specimen
#0035
status: complete
- sequence
- HAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG
- from wallet
- 6F4J6AdT5iQx4ExeN7JFE7EEM6fJ1XJ3DRUHT56gMfWF
- amount paid
- 0 SOL
- transaction
- 5KUmm2Je1MUWY9Yhgbpog7SNbPUhUmpXvnKQLqpYWQLhmmZPHZPeBENhuHWPTykWvY5gPdQiqGCUYib4BoWRwoqb ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence61%confidence 52% · band 49-73%ESMFold esmatlas-esmfold-v1disorder estimate68%confidence 52% · band 56-80%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk34%confidence 56% · band 23-45%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden42%confidence 84% · band 38-46%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk3%confidence 84% · band 0-7%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk30%confidence 56% · band 19-41%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: predicted disorder is elevated
- audit trail
- run: run_11c5a667e6f64d6187a829ed14e19ed3seq sha256: 7eac900d189747fcc34fe30e332a690bcf6123cf3280bd014641a3b5a619ab77report sha256: a12b286fabcfc78af54dd3bbdf09b20f4857d7efc566866a0eae2d8b30cc20a8pepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “that's semaglutide's backbone, more or less. fully unstructured on its own, which tracks. glp-1 analogs only fold when they find their receptor, otherwise they just dangle there waiting.”
- device photo
- created
- Tue, 16 Jun 2026 04:03:24 GMT
- completed
- Tue, 16 Jun 2026 04:16:23 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: long hydrophobic run may increase aggregation risk. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 1 motif liability flag(s) in the sequence - 2. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 68% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.