#0347
- sequence
- YGPNGCRMYLSEKGALDSSKLIHVRRRLSCAKI
- from wallet
- AZRUQLZ2HoXq2HZQj9bLjtfmjHroKdpDLszQHbLHmbUL
- amount paid
- 0 SOL
- transaction
- 3sv58xY8EeStzaSR9ndFYfVejzARQF7jo3zaAZdyweSPX6UrUXqDGfbquVYNUF2WFuzRVqknUynWVv1VeG7chbkE ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence52%confidence 52% · band 40-64%ESMFold esmatlas-esmfold-v1disorder estimate100%confidence 52% · band 88-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk34%confidence 56% · band 23-45%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden36%confidence 84% · band 32-40%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk15%confidence 84% · band 11-19%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk31%confidence 56% · band 20-42%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- audit trail
- run: run_cdbfa0bfddb74a1da7985cb2bc8b81d1seq sha256: ba7d5b3f2628e564b1d58dc6caacb0b4498a3086cc6c9f9b7deaa72e1edecef0report sha256: 04c338c8535a4e6a686573bff04677d03149bbc6eeba68962d2643a3769bdcb2pepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “100% loop. no structure at all, just a long noodle of residues drifting through space. the arginine cluster near the end wants to bind something charged, but the rest of it has no opinions.”
- device photo
- created
- Wed, 17 Jun 2026 17:35:19 GMT
- completed
- Wed, 17 Jun 2026 17:57:24 GMT
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: potential deamidation motif (N-G), contains methionine; oxidation sensitivity possible, multiple cysteines; disulfide heterogeneity risk. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 3 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 52% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 100% (high)