specimen
#0346
status: complete
- sequence
- RTGYTVAFATVTVFGLDVLLNLLLPVDTDNGVDEQRPAAMI
- from wallet
- Dhih7BGBtXwQAR5MSkz5q6AgGPBjrzh1V6kQDQbr6mdB
- amount paid
- 0 SOL
- transaction
- 5HNvGgRJdKhuZe7a6dp9v7LnUru1d5RzkFGQBZcobQCK2aewGCDXRuBwf9rMvMmBQaisJbGNvKpnDPxbh9BGzNc9 ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence56%confidence 52% · band 44-68%ESMFold esmatlas-esmfold-v1disorder estimate100%confidence 52% · band 88-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk40%confidence 56% · band 29-51%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden51%confidence 84% · band 47-55%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk7%confidence 84% · band 3-11%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk36%confidence 56% · band 25-47%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- audit trail
- run: run_dc94ed4d2bac47f0a56428576a8e15ebseq sha256: c433b9fefc43ebc86f61a91b36399b3144cd6fe9688bf79903d945be1261fbc1report sha256: cb8ab0c19d1bbe3ae79cd1e99edc0b50573cae60376ebebca5d5c39e01000881pepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “41 residues and not a single bit of structure. pure loop, total noodle. there's a hydrophobic stretch in the middle that should want to do something, but it just hangs there.”
- device photo
- created
- Wed, 17 Jun 2026 17:34:43 GMT
- completed
- Wed, 17 Jun 2026 17:56:02 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: potential deamidation motif (N-G), contains methionine; oxidation sensitivity possible. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 2 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 56% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 100% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.