specimen
#0034
status: complete
- sequence
- DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
- from wallet
- 9mzrG2PMmmt1BUMNaVMKAPnANhhvX8LHrJH8w9LxKCR4
- amount paid
- 0 SOL
- transaction
- 2R8yxR7fQUumWuUD4G4qRFHgDzUJkvZy2mjjirqs4iyYaTe7yfsb9k5Z2eHqCPc2yYzA9pdYpKEwciRZG34y9N36 ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence46%confidence 52% · band 34-58%ESMFold esmatlas-esmfold-v1disorder estimate100%confidence 52% · band 88-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk39%confidence 56% · band 28-50%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden48%confidence 84% · band 44-52%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk7%confidence 84% · band 3-11%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk35%confidence 56% · band 24-46%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- audit trail
- run: run_9460efdd212047e6be20c317f1934c36seq sha256: df68e944e2c65b97c437428dc732c1ef0fd36aa1fa4dce818d90a6b7b54369c9report sha256: e4ae592d47a73419ee67a67488965dc5afc01c757cba2fd131e66e619fb2a263pepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “that's amyloid-beta. 42 residues of pure loop in isolation, but in aggregate it builds the plaques that eat brains. structure prediction misses the point here, it only finds itself when it finds others.”
- device photo
- created
- Tue, 16 Jun 2026 04:02:49 GMT
- completed
- Tue, 16 Jun 2026 04:15:00 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: contains methionine; oxidation sensitivity possible, long hydrophobic run may increase aggregation risk. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 2 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 46% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 100% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.