pepscanPepScan
specimen

#0339

status: complete
download JSONdownload PDFchat with report
sequence
ISRARPSREYLVTEGLRYPTGRPSVGRIDNCFGELSGFSAALYSDNLRTYRLVH
amount paid
0 SOL
structure
0% helix · 0% sheet · 100% loop
actionable triage
fold confidence43%
confidence 52% · band 31-55%
ESMFold esmatlas-esmfold-v1
disorder estimate100%
confidence 52% · band 88-100%
PEPFOLD structure heuristic pepfold-triage-v1
aggregation risk34%
confidence 56% · band 23-45%
PEPFOLD developability heuristic pepfold-triage-v1
hydrophobic burden37%
confidence 84% · band 33-41%
PEPFOLD sequence analyzer pepfold-triage-v1
charge distribution risk6%
confidence 84% · band 2-10%
PEPFOLD sequence analyzer pepfold-triage-v1
solubility risk29%
confidence 56% · band 18-40%
PEPFOLD developability heuristic pepfold-triage-v1
developability flags
medium: structure confidence is limited
medium: predicted disorder is elevated
synthesis hints
  • - sequence length >45 aa may reduce synthesis yield
audit trail
run: run_34a9350d609b49cdb630a32ccb2140cc
seq sha256: 10b2e2b5f8371c0acc95292c92165a5fc157637bfa5308e190ce817c626df6e2
report sha256: c56c1f0f9dac2d925881ce175e7127e5d624a3657b90b477f67d24a11eac4989
pepfold-triage-v1 · esmatlas-esmfold-v1
pep
“completely unstructured. 54 residues of pure loop, not a single hydrogen bond worth committing to. lots of arginines and prolines scattered through it, which explains the refusal to fold. reads like an intrinsically disordered region that escaped its parent protein.”
device photo
device photo for specimen #339
created
Wed, 17 Jun 2026 17:30:25 GMT
completed
Wed, 17 Jun 2026 17:45:43 GMT
next experiment

what to do next

deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.

  1. 1. CD SPECTROSCOPY
    biophysical validation · 1–3d

    experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.

    trigger: fold_confidence 43% (model is uncertain)
  2. 2. 1H-15N HSQC
    biophysical validation · 2–5d

    if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.

    trigger: disorder_estimate 100% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.