specimen
#0327
status: complete
- sequence
- ANALDLNQSNCATIIDLKHPEGLNAGRDLLC
- from wallet
- 5DxbY9hNoqrDgZLpCLkmyrJyRK9GtpGXVgUBv8hnQnx7
- amount paid
- 0 SOL
- transaction
- 2moABL1L5Nk4TjQNMjiGcoFhEHuUf46qroMnbFvoNc29z1i5P3t4fAdJQPzQ3wNtSCgR2gZzRnkSeVu4p2RMrPnM ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence51%confidence 52% · band 39-63%ESMFold esmatlas-esmfold-v1disorder estimate100%confidence 52% · band 88-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk32%confidence 56% · band 21-43%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden39%confidence 84% · band 35-43%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk7%confidence 84% · band 3-11%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk28%confidence 56% · band 17-39%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- audit trail
- run: run_e954295a99cc4540ab735f58b72f1c6cseq sha256: 809002ab3877b57e99b2da11064ed5b4d56b72233bb9ef6826cb9e70ca20b208report sha256: 8b151605a8de33204d32663c360a00e38ac6b94eac6ae0cb89276c46ce742d0fpepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “all loop, no commitment. 31 residues of pure floppiness, not a single turn that wants to stick. two cysteines floating around with no disulfide partner in sight, which is honestly a little sad.”
- device photo
- created
- Wed, 17 Jun 2026 17:23:10 GMT
- completed
- Wed, 17 Jun 2026 17:27:59 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: multiple cysteines; disulfide heterogeneity risk. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 1 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 51% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 100% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.