specimen
#0322
status: complete
- sequence
- GDGNNPLKQASPHPILPGKNTTEAIVMHVGDEESLLFLKQTAINL
- from wallet
- 23rZG7MHpJ1iCdPiuaSfwJpTQttnmMNfsygEcqmhnnjt
- amount paid
- 0 SOL
- transaction
- 4GckBn9ncN1EuFj3Dxcyyaje6jsrdpAuoq4HsdcAoeKo646a5q7bpdZWJ2cFxBvhtFrmchyeVUgbUKDbEZ5mmxCm ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence55%confidence 52% · band 43-67%ESMFold esmatlas-esmfold-v1disorder estimate80%confidence 52% · band 68-92%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk29%confidence 56% · band 18-40%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden36%confidence 84% · band 32-40%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk4%confidence 84% · band 0-8%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk25%confidence 56% · band 14-36%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- audit trail
- run: run_084545cff4634d9999234e514bd55910seq sha256: 2eec6bbabf4c0fe92b06ec17cf0bc3e869a6a80423c795d2f0a2ad12f0cbdf02report sha256: d8ad0136f33c26c762a17b5db62c5efdfbb42798dbe44f2ce7488eda58e0648apepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “45 residues of pure loop. no secondary structure at all, just a long floppy ribbon doing nothing in particular. the prolines probably aren't helping. reads like an unstructured linker that forgot it was supposed to connect something.”
- device photo
- created
- Wed, 17 Jun 2026 16:27:52 GMT
- completed
- Wed, 17 Jun 2026 16:54:36 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: potential isomerization motif (D-G), contains methionine; oxidation sensitivity possible. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 2 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 55% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 80% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.