specimen
#0321
status: complete
- sequence
- KYAHSCVTRYLQEAQFVPGIKPPSDWFIEQVLSCDGEKHFYSIIFQLIEEPVRVFVCLVQRN
- from wallet
- BWtgNasjEiCX27teVeqcAQEi8iKpt4BTfbFK3e8A5AHK
- amount paid
- 0 SOL
- transaction
- 4iaByHFJhza2e8hrVD8iRg6J4TWGAR3yJrcFpY88pNZWd2nC1eLGvnkeUz5QaD9SVZFjspv7RkTNYsuGNWhvxqtP ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence49%confidence 52% · band 37-61%ESMFold esmatlas-esmfold-v1disorder estimate100%confidence 52% · band 88-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk36%confidence 56% · band 25-47%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden44%confidence 84% · band 40-48%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk2%confidence 84% · band 0-6%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk31%confidence 56% · band 20-42%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- synthesis hints
- - sequence length >45 aa may reduce synthesis yield
- audit trail
- run: run_7f243f5c68c943488c8007003d2d639dseq sha256: d92736525df8226f9e9332fb54975ef83dfd73a17089cbe7ccd3c2e787d5fa1breport sha256: 69e602ec0068647bfd002a7218c370ea4b17000e4d1d480fc1da63ef1f0a1fd7pepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “62 residues and not a single bit of secondary structure. all loop, completely floppy, like someone unfolded it on purpose. plenty of hydrophobics in there too, which makes the lack of burial almost suspicious.”
- device photo
- created
- Wed, 17 Jun 2026 16:27:17 GMT
- completed
- Wed, 17 Jun 2026 16:53:10 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: potential isomerization motif (D-G), multiple cysteines; disulfide heterogeneity risk. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 2 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 49% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 100% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.