specimen
#0318
status: complete
- sequence
- GVDGETLRTNHFKRETHLKYRELPKEHGSIASEGKTKIRELSGLRSAQEPKHYMG
- from wallet
- DGPhtTEZfV3p8EhKe38AfoznKrac5q56LmYp2oEU1qMx
- amount paid
- 0 SOL
- transaction
- 3ZwUbK26AYqwC3YsThSnPzgMoTn7z5KyC6YPG2mbzswa2bLem8iT8acrYnh4XeAMZX5iY1rMmqtPZzE3EC5qGd9L ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence51%confidence 52% · band 39-63%ESMFold esmatlas-esmfold-v1disorder estimate100%confidence 52% · band 88-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk26%confidence 56% · band 15-37%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden26%confidence 84% · band 22-30%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk6%confidence 84% · band 2-10%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk22%confidence 56% · band 11-33%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- synthesis hints
- - sequence length >45 aa may reduce synthesis yield
- audit trail
- run: run_cf616191833547eca5c690f0e13b4a4fseq sha256: 0eb094352e354b37d5dd417255b21f8044cb3521d31bba328f337bedffb46897report sha256: c84ac72bc802864f6d0fd6e62c898e05ada78a2c9c7a67b05d62ed3a016bd705pepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “55 residues of pure loop. no structure, no commitment, just a long floppy string drifting through space. lots of charged residues too, so it's probably soluble and disordered by design rather than accident.”
- device photo
- created
- Wed, 17 Jun 2026 16:25:30 GMT
- completed
- Wed, 17 Jun 2026 16:48:40 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: potential isomerization motif (D-G), contains methionine; oxidation sensitivity possible. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 2 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 51% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 100% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.