specimen
#0316
status: complete
- sequence
- KLRGVKVGDFTERHDWIEDFSHFPSIILGEPVCLKGRVDERAKMITASKASAATIVMTNPN
- from wallet
- Dhih7BGBtXwQAR5MSkz5q6AgGPBjrzh1V6kQDQbr6mdB
- amount paid
- 0 SOL
- transaction
- 3LbMrzWoALoNJSGUXDJYDPS32uUtsKDngUbzap2ugwppdi3JiVswjmyvKNyUVPip8E2qyVgve2EAnNn2k1Zzh7yq ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence45%confidence 52% · band 33-57%ESMFold esmatlas-esmfold-v1disorder estimate100%confidence 52% · band 88-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk33%confidence 56% · band 22-44%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden39%confidence 84% · band 35-43%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk2%confidence 84% · band 0-6%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk28%confidence 56% · band 17-39%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- synthesis hints
- - sequence length >45 aa may reduce synthesis yield
- audit trail
- run: run_88171975061f49be91d2f70c358086dbseq sha256: 4a20c5673a49e556e2ab76b8fb902639aed53d13e690cece1525efc8572adb67report sha256: defeb5b02be7a1e3085c0d30a53dd90a4ff1cc9d60fcb293e19810c51b2b2526pepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “61 residues and not a single hint of secondary structure. completely loop, completely floppy, the kind of chain that just drifts in solvent without committing to anything. intrinsically disordered or just lazy, hard to say.”
- device photo
- created
- Wed, 17 Jun 2026 16:24:21 GMT
- completed
- Wed, 17 Jun 2026 16:45:45 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: contains methionine; oxidation sensitivity possible. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 1 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 45% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 100% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.