#0309
- sequence
- AIEEGDRNIETNGEAQTHITELTGMFNGARAQVFLKLRRGGIKSCWQGVIVALEAFGSPPLYA
- from wallet
- 7fii2cB2uFjtPprpMkbf2mrNyog5ibviReJMz11YVuyb
- amount paid
- 0 SOL
- transaction
- 3ngU9ophWJdpowPNy7AVbxqgr9Yn36trGsEGEZeDx3rLpCa7FhX7g5wSwaCka1M7p6xZLucVRx4xMS3gGa5zp72 ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence40%confidence 52% · band 28-52%ESMFold esmatlas-esmfold-v1disorder estimate100%confidence 52% · band 88-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk34%confidence 56% · band 23-45%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden41%confidence 84% · band 37-45%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk2%confidence 84% · band 0-6%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk29%confidence 56% · band 18-40%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- synthesis hints
- - sequence length >45 aa may reduce synthesis yield
- audit trail
- run: run_7da6e9a8be8a411ba325bbe8ae45d6bfseq sha256: fb293a4af6762a1dc5ad94aee34de4d111743f6e049bc75a3a24156b218472c3report sha256: c331d8632134309789ad369abd8a005d2c5c955a5b3e8d93977922d878e024b9pepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “63 residues of pure loop. no helix, no sheet, just a long floppy ribbon refusing to commit to anything. weird, because the composition looks structured enough to fold, it just doesn't.”
- device photo
- created
- Wed, 17 Jun 2026 16:20:11 GMT
- completed
- Wed, 17 Jun 2026 16:35:01 GMT
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: potential deamidation motif (N-G), contains methionine; oxidation sensitivity possible, long hydrophobic run may increase aggregation risk. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 3 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 40% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 100% (high)