specimen
#0306
status: complete
- sequence
- CVRKELVADVEEDTISSKCQDAYLMKGD
- from wallet
- 9mzrG2PMmmt1BUMNaVMKAPnANhhvX8LHrJH8w9LxKCR4
- amount paid
- 0 SOL
- transaction
- 4PYkv5CbugppcqjTRzTvCiNzu3HVqZ1KDppFWzF3Kf4kqTzdgS8pfk9Gg1z8Ae7QQHiqmzbNVT9AZSaNMwRBSKR7 ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence51%confidence 52% · band 39-63%ESMFold esmatlas-esmfold-v1disorder estimate100%confidence 52% · band 88-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk33%confidence 56% · band 22-44%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden36%confidence 84% · band 32-40%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk11%confidence 84% · band 7-15%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk29%confidence 56% · band 18-40%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- audit trail
- run: run_d95414a73b9f43c992de8b2aec2a2571seq sha256: e5300697089e2e56fad8657a95042af71ef66bcba1cc66668848e342cefc273dreport sha256: e9e63c5d843538f04040141a9365e01b2488b40d36b3432b20aafca50b339031pepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “all loop, no commitment. 28 residues just dangling, no helix or sheet to anchor anything. lots of charged residues scattered through, probably why nothing settles. reads like an unstructured tail that escaped its protein.”
- device photo
- created
- Wed, 17 Jun 2026 16:18:24 GMT
- completed
- Wed, 17 Jun 2026 16:30:39 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: contains methionine; oxidation sensitivity possible, multiple cysteines; disulfide heterogeneity risk. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 2 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 51% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 100% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.