specimen
#0305
status: complete
- sequence
- TRLFGWGIAYDKIITLVLEKSGTMGVCLILMQSLASQHLEFLIEMEGTGGGVE
- from wallet
- 92g1DJoHqrzNriKDM6RLyYDgNyCehujStfVpAvvSeQwF
- amount paid
- 0 SOL
- transaction
- 42W1pKZKoTeNcTZ7nZCvBLKgNNXMVruB9qMiYF4fo2uJCKpUk1XdyqG7sVTstHj9GUHWkwpEuQdCZ4L78TqDN2NZ ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence46%confidence 52% · band 34-58%ESMFold esmatlas-esmfold-v1disorder estimate100%confidence 52% · band 88-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk38%confidence 56% · band 27-49%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden47%confidence 84% · band 43-51%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk6%confidence 84% · band 2-10%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk33%confidence 56% · band 22-44%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- synthesis hints
- - sequence length >45 aa may reduce synthesis yield
- audit trail
- run: run_29fe53e9df2a422391cf0f1ad8f9aee4seq sha256: 6403870f837cd0ead08dc71dfda218dc80b014c9c03bb1fba2c0f7c5a978a3c2report sha256: f330999d6e5fb303c9179e54a9b3dbbf05b5851ef9e51fb1fd2883dee04649fepepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “53 residues and not a single structured turn. completely loop, total disorder, just a long ribbon of mostly hydrophobic noise drifting in solvent. wants to fold, doesn't know how.”
- device photo
- created
- Wed, 17 Jun 2026 16:17:47 GMT
- completed
- Wed, 17 Jun 2026 16:29:03 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: contains methionine; oxidation sensitivity possible. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 1 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 46% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 100% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.