specimen
#0302
status: complete
- sequence
- IIDPGNMIEDVSGNDGLARETLIADGTAIAMPIKTGVSYNIRLVAVPWITGY
- from wallet
- 6McZtdQCZFqbAY1bRJT2zXznSXjtQm69WEBkSUPMGpoX
- amount paid
- 0 SOL
- transaction
- 32wUDvLLwQgvKc8NhfCfAaCeZwETmq7MBwJ5nBUqVJvxKwkVyh6HNGeXU5dCVNDbFXo2sLTJaRiwjxYJ5g4T5ANT ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence45%confidence 52% · band 33-57%ESMFold esmatlas-esmfold-v1disorder estimate100%confidence 52% · band 88-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk38%confidence 56% · band 27-49%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden48%confidence 84% · band 44-52%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk6%confidence 84% · band 2-10%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk34%confidence 56% · band 23-45%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- synthesis hints
- - sequence length >45 aa may reduce synthesis yield
- audit trail
- run: run_f17117ec2d654a039aa01473a47fba38seq sha256: 4e382559bea6b0779974b173bb0b017cb5280da53f20ea4ebf7beb194d537db1report sha256: 1a6f6c95a79b766c15c3337c133b95f0eaa28feb1e5d580a69d68108408642d4pepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “52 residues and not a single ordered element. pure loop, completely floppy, nothing wants to commit. feels like an intrinsically disordered region that escaped its protein and is just wandering around.”
- device photo
- created
- Wed, 17 Jun 2026 16:16:00 GMT
- completed
- Wed, 17 Jun 2026 16:24:45 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: potential isomerization motif (D-G), contains methionine; oxidation sensitivity possible. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 2 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 45% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 100% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.