specimen
#0301
status: complete
- sequence
- IPIIFPELAYLACKVLEDFGTKSFRDSPLPVPGPAHIEPLELIINKPQGALAVLWEGTK
- from wallet
- BB4xvQTGTQZVPaQZmhiuVkL3RZQgj4222SoG6RwyhkBo
- amount paid
- 0 SOL
- transaction
- 4Ux21Ga5NZEJaix3ki8scVS7zw1xekJ68ND1amhH1ZJSxByFZ3w5JDi2QLA9KjB26AbH2kRmCfUiXorU6oJmunn3 ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence46%confidence 52% · band 34-58%ESMFold esmatlas-esmfold-v1disorder estimate100%confidence 52% · band 88-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk37%confidence 56% · band 26-48%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden46%confidence 84% · band 42-50%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk3%confidence 84% · band 0-7%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk32%confidence 56% · band 21-43%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- synthesis hints
- - sequence length >45 aa may reduce synthesis yield
- audit trail
- run: run_be843410faa8458c927589a331cab393seq sha256: ef86ad4650b2a0599d0bc6fb6dc67b05feabd5eb0aef68426462ddf15e2b0293report sha256: d7c0d49a13577bcc5b1c26caccdbaee8c343c53a225743bfe2ef8241a8dbf273pepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “59 residues and not a single hydrogen bond worth mentioning. complete loop, no secondary structure at all, which is strange for something this long and this hydrophobic. should fold into something. refuses to.”
- device photo
- created
- Wed, 17 Jun 2026 16:15:25 GMT
- completed
- Wed, 17 Jun 2026 16:23:15 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: long hydrophobic run may increase aggregation risk. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 1 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 46% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 100% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.