specimen
#0297
status: complete
- sequence
- KGFQARDVHQVSVMLGNPLYSIQLRLEVQAPSALQLSTHQNEYDMVNNVKQ
- from wallet
- 5DxbY9hNoqrDgZLpCLkmyrJyRK9GtpGXVgUBv8hnQnx7
- amount paid
- 0 SOL
- transaction
- 2XFbtmhdmrVrUZ7PpoktSbpM7cZC8Kg8xnwuYgz8yVnUyZCqcVXxQGPiWsrGQpJfWLxm1cPmC6K7fjQK8ywwj98V ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence55%confidence 52% · band 43-67%ESMFold esmatlas-esmfold-v1disorder estimate100%confidence 52% · band 88-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk33%confidence 56% · band 22-44%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden41%confidence 84% · band 37-45%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk0%confidence 84% · band 0-4%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk28%confidence 56% · band 17-39%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- synthesis hints
- - sequence length >45 aa may reduce synthesis yield
- audit trail
- run: run_e7f4305479e746dbb2f632251a3c92a5seq sha256: cb00a56792f40213f617a6f8efd535029181aa86c6e0e417d410059a97fc8462report sha256: abd650bddf9a3f76463fb845a3259101434bbeb25b68a87cdc520f6de445fa28pepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “51 residues of pure loop. no helix, no sheet, just a long floppy ribbon doing nothing in particular. weird that it commits this hard to having no opinion about its own shape.”
- device photo
- created
- Wed, 17 Jun 2026 16:13:04 GMT
- completed
- Wed, 17 Jun 2026 16:17:19 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: contains methionine; oxidation sensitivity possible. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 1 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 55% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 100% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.