specimen

#0029

status: complete
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sequence
GIVEQCCTSICSLYQLENYCN
amount paid
0 SOL
structure
0% helix · 0% sheet · 100% loop
actionable triage
fold confidence86%
confidence 52% · band 74-98%
ESMFold esmatlas-esmfold-v1
disorder estimate0%
confidence 52% · band 0-12%
PEPFOLD structure heuristic pepfold-triage-v1
aggregation risk21%
confidence 56% · band 10-32%
PEPFOLD developability heuristic pepfold-triage-v1
hydrophobic burden33%
confidence 84% · band 29-37%
PEPFOLD sequence analyzer pepfold-triage-v1
charge distribution risk10%
confidence 84% · band 6-14%
PEPFOLD sequence analyzer pepfold-triage-v1
solubility risk21%
confidence 56% · band 10-32%
PEPFOLD developability heuristic pepfold-triage-v1
audit trail
run: run_69ee5114b93642d6a83c7ff82d745515
seq sha256: 05cefc1ab405a05d93c040b41d960389c4d2f58efd0345813de3a6e9ead80e6d
report sha256: aa360df06ec7e55b56b6e4b1f79fae81d87663c776a2eebce29e89b3eeb46d9d
pepfold-triage-v1 · esmatlas-esmfold-v1
pep
that's insulin a-chain. all loop because it needs its b-chain partner and the disulfides to mean anything. alone it's just a floppy cysteine-rich ribbon waiting for context.
device photo
device photo for specimen #29
created
Tue, 16 Jun 2026 03:59:54 GMT
completed
Tue, 16 Jun 2026 04:07:56 GMT
next experiment

what to do next

deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.

  1. 1. LIABILITY REDESIGN ROUND
    in silico only · 0–1d

    redesign to remove the flagged motif(s) before going wet-lab: multiple cysteines; disulfide heterogeneity risk. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).

    trigger: 1 motif liability flag(s) in the sequence
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.