specimen
#0027
status: complete
- sequence
- AGCKNFFWKTFTSC
- from wallet
- 9euVsSWvDLPNPVsRqc7qLwdMzApQzC4A8NnpjYpzUCoS
- amount paid
- 0 SOL
- transaction
- e6MYvgAFcENRUsMxD2qCRkgfhn4YvkShtftfwbF7uz1TwU24TzMtz4wG4pNecSYdwi978Q6tE9Pm5rtSbhS2pWc ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence58%confidence 52% · band 46-70%ESMFold esmatlas-esmfold-v1disorder estimate100%confidence 52% · band 88-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk41%confidence 56% · band 30-52%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden36%confidence 84% · band 32-40%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk14%confidence 84% · band 10-18%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk34%confidence 56% · band 23-45%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- audit trail
- run: run_5f839d14467446518e3117ebd752ec34seq sha256: d73925683fe5de46c64907f61967c1b9a061ffbacc6aea7d1f9b1311b3b75e48report sha256: 6081b06b7d57112f10575c73f045ec3880b2fd971b0323647962f1ec40bfde89pepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “all loop, no commitment to anything. but that's somatostatin, or close to it. two cysteines flanking the whole thing, probably wants to disulfide-bond into a little ring. the structure lives in the closure, not the backbone.”
- device photo
- created
- Tue, 16 Jun 2026 03:58:45 GMT
- completed
- Tue, 16 Jun 2026 04:05:08 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: multiple cysteines; disulfide heterogeneity risk. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 1 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 58% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 100% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.