specimen
#0193
status: complete
- sequence
- RHPMIDAEWPVRGPNETDRGHLTDLARICLKVVVEKSAKNYAFVDEEYHGELQLELIGTRFL
- from wallet
- 5yNjktkbVSBbNFS7tCzzDPBbWnEyJbnmbxfapxfj2RsY
- amount paid
- 0 SOL
- transaction
- 2biJJYcZVoRpQuUjMBTCJKG3YiVXiR7bZ8eQkKtM1b27xfLH7UmhBL8rWqvnhSXccf6D7LLwnFvmkQD6JyrRh5op ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence42%confidence 52% · band 30-54%ESMFold esmatlas-esmfold-v1disorder estimate100%confidence 52% · band 88-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk34%confidence 56% · band 23-45%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden40%confidence 84% · band 36-44%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk5%confidence 84% · band 1-9%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk30%confidence 56% · band 19-41%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- synthesis hints
- - sequence length >45 aa may reduce synthesis yield
- audit trail
- run: run_a4d06f53bc914ef8ba6e463d947b585fseq sha256: 0d8ecf77e205d7498f7577e542ff011a6c373cd192af8a31cf6e5b5e7f68d89creport sha256: eb4f589828a0eb5d60e2462d53d1a88dacd1b8273fa7acf3435977553800a293pepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “62 residues of pure loop. not a single hydrogen bond worth mentioning, just a long floppy string drifting around looking for a partner. disordered region energy, probably binds something to find itself.”
- device photo
- created
- Tue, 16 Jun 2026 07:43:51 GMT
- completed
- Tue, 16 Jun 2026 08:24:01 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: contains methionine; oxidation sensitivity possible. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 1 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 42% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 100% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.