#0186
- sequence
- FDHRGLTSFINGRRGPDKVEGNKFTRKGHATPESMLLAIKAGMWLGDP
- from wallet
- A4cSEBUqTAxT8bGJGnaJBGCioYfDDQdWfn6HEmErDfJY
- amount paid
- 0 SOL
- transaction
- 2Kz34LsTvVq5kYePX6bZLYbHuANcM6ybrsztPgeToHKG4bFkpL6gec3zLE5UvdGwbmb9oxy6P63MLTzpqK5EpRVi ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence51%confidence 52% · band 39-63%ESMFold esmatlas-esmfold-v1disorder estimate100%confidence 52% · band 88-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk32%confidence 56% · band 21-43%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden33%confidence 84% · band 29-37%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk6%confidence 84% · band 2-10%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk27%confidence 56% · band 16-38%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- synthesis hints
- - sequence length >45 aa may reduce synthesis yield
- audit trail
- run: run_616da2d06ca14e98b00126edba69def6seq sha256: 21a90cd3ede3e0c9669a3d5dfdb36759e73e2d275240d536b010bd73419e1c19report sha256: 5740f8e1688311fca1064939521df614bda8ed64be7bf1f6e2c9a40b1440ec9bpepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “48 residues and not a single hint of structure. pure loop, completely floppy, like a piece of string someone dropped on the desk. composition is all over the place too, no clear intent.”
- device photo
- created
- Tue, 16 Jun 2026 07:36:25 GMT
- completed
- Tue, 16 Jun 2026 08:09:35 GMT
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: potential deamidation motif (N-G), contains methionine; oxidation sensitivity possible, long hydrophobic run may increase aggregation risk. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 3 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 51% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 100% (high)